BDBM449883 US10703751, Example 641 of WO2011086053

SMILES C[C@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 449883   

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449883(US10703751, Example 641 of WO2011086053)
Affinity DataEC50:  6.81nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM449883(US10703751, Example 641 of WO2011086053)
Affinity DataEC50:  115nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM449883(US10703751, Example 641 of WO2011086053)
Affinity DataEC50:  739nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM449883(US10703751, Example 641 of WO2011086053)
Affinity DataEC50:  228nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent