BDBM450060 9-{4-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]benzyl}-8-(5-fluoropyridin-3-yl)-2-methoxy-6-methyl-9H-purine; 9-{4-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]benzyl}-8-(5-fluoropyridin-3-yl)-2-methoxy-6-methyl-9H-purine::US10703755, Example 177::US10703755, Example 178

SMILES COc1nc(C)c2nc(-c3cncc(F)c3)n(Cc3ccc(cc3)[C@H]3CN4CCC3CC4)c2n1

InChI Key InChIKey=OMRJSHXWBUUQRV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 450060   

TargetToll-like receptor 7(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM450060(US10703755, Example 178 | 9-{4-[(3R)-1-Azabicyclo[...)
Affinity DataIC50: 3nMAssay Description:As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter HEK293 cell), which is human embr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM450060(US10703755, Example 178 | 9-{4-[(3R)-1-Azabicyclo[...)
Affinity DataIC50: 10nMAssay Description:As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter HEK293 cell), which is human embr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent