BDBM450560 N-[(4-Chloro-3-cyanophenyl)methyl]-N-methyl-2-[4-oxo-6-[1-(oxolan-3-ylmethyl)piperidin-4-yl]quinazolin-3-yl]acetamide::US10676446, Example 144

SMILES CN(Cc1ccc(Cl)c(c1)C#N)C(=O)Cn1cnc2ccc(cc2c1=O)C1CCN(CC2CCOC2)CC1

InChI Key InChIKey=NCWGMOMGBKCPHN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450560   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 450560BDBM450560(US10676446, Example 144 | N-[(4-Chloro-3-cyanophen...)
Affinity DataIC50: 86nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent