BDBM450639 2-{6-[2-(4-Chloro-2-fluorophenyl)-2-methyl-1,3-benzodioxol-4-yl]-6-azaspiro[2.5]oct-1-yl}-1-(2-methoxyethyl)-1H-benzimidazole-6-carboxylic Acid, DIAST-X1, Trifluoroacetate Salt (15) [from P18 Via C71]; and 2-{6-[2-(4-Chloro-2-fluorophenyl)-2-methyl-1,3-benzodioxol-4-yl]-6-azaspiro[2.5]oct-1-yl}-1-(2-methoxyethyl)-1H-benzimidazole-6-carboxylic Acid, DIAST-X2, Trifluoroacetate Salt (16) [from P18 Via C72]::US10676465, Example 16

SMILES COCCn1c(nc2ccc(cc12)C(=O)OC)[C@H]1CC11CCN(CC1)c1cccc2OC(C)(Oc12)c1ccc(Cl)cc1F

InChI Key InChIKey=GAZVOJHPIOZHSZ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 450639   

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandPNGBDBM450639(US10676465, Example 16 | 2-{6-[2-(4-Chloro-2-fluor...)
Affinity DataEC50:  7.70nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandPNGBDBM450639(US10676465, Example 16 | 2-{6-[2-(4-Chloro-2-fluor...)
Affinity DataEC50:  120nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent