BDBM450668 2-({4-[2-(4-chloro-2-fluorophenyl)-2- methyl-1,3-benzodioxol-4-yl]piperidin-1- yl}methyl)-1-(pyridin-2-ylmethyl)-1H- benzimidazole-6-carboxylic acid::US10676465, Example 45

SMILES CC1(Oc2cccc(C3CCN(Cc4nc5ccc(cc5n4Cc4ccccn4)C(O)=O)CC3)c2O1)c1ccc(Cl)cc1F

InChI Key InChIKey=HTPJVSOAINTYKD-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 450668   

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandPNGBDBM450668(US10676465, Example 45 | 2-({4-[2-(4-chloro-2-fluo...)
Affinity DataEC50:  9.90nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandPNGBDBM450668(US10676465, Example 45 | 2-({4-[2-(4-chloro-2-fluo...)
Affinity DataEC50:  220nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent