BDBM450720 2-({4-[2-(4-chloro-2-fluorophenyl)-7- fluoro-2-methyl-1,3-benzodioxol-4- yl]piperidin-1-yl}methyl)-1-[(2S)-oxetan- 2-ylmethyl]-1H-benzimidazole-6- carboxylic acid, DIAST-1 [footnote 10 in Table 2]::US10676465, Example 96::US10676465, Example 97

SMILES CC1(Oc2c(O1)c(ccc2F)C1CCN(Cc2nc3ccc(cc3n2C[C@@H]2CCO2)C(O)=O)CC1)c1ccc(Cl)cc1F

InChI Key InChIKey=IIDQXCXBRQKHNZ-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 450720   

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandPNGBDBM450720(US10676465, Example 96 | 2-({4-[2-(4-chloro-2-fluo...)
Affinity DataEC50:  1.10nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandPNGBDBM450720(US10676465, Example 96 | 2-({4-[2-(4-chloro-2-fluo...)
Affinity DataEC50:  11nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandPNGBDBM450720(US10676465, Example 96 | 2-({4-[2-(4-chloro-2-fluo...)
Affinity DataEC50:  14nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandPNGBDBM450720(US10676465, Example 96 | 2-({4-[2-(4-chloro-2-fluo...)
Affinity DataEC50:  140nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent