BDBM450753 US10676467, Compound TZ 35 115

SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(OCCF)cc2)C1

InChI Key InChIKey=RVFFFKILMXZNGG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450753   

TargetSphingosine 1-phosphate receptor 1(Human)
Washington University

US Patent
LigandPNGBDBM450753(US10676467, Compound TZ 35 115)
Affinity DataIC50: 9.94nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Washington University

US Patent
LigandPNGBDBM450753(US10676467, Compound TZ 35 115)
Affinity DataIC50: 1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Washington University

US Patent
LigandPNGBDBM450753(US10676467, Compound TZ 35 115)
Affinity DataIC50: 1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent