BDBM450968 8-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,5-c]pyrimidine-1-carbonitrile::US10676479, Example 5

SMILES Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnc(C#N)c23)n(C)n1

InChI Key InChIKey=YJHCUUIBUCMIFB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450968   

LigandPNGBDBM450968(8-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3...)
Affinity DataIC50:  3.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM450968(8-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3...)
Affinity DataIC50:  3.20nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM450968(8-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3...)
Affinity DataIC50:  8.90nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent