BDBM451070 N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-::US10676479, Example 100

SMILES CS(=O)(=O)c1ncn2c(NCc3c4CCOc4ccc3F)ncc(-c3ccc(cc3)S(C)(=O)=O)c12

InChI Key InChIKey=JOAXXJJQMAVHPP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451070   

LigandPNGBDBM451070(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...)
Affinity DataIC50:  4.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451070(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of EED ( 1 to 441 residues) (unknown origin) pre-incubated for 15 mins before biotin-H3K27me3 (19 to 33 residues) addition and further inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM451070(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...)
Affinity DataIC50:  0.600nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM451070(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...)
Affinity DataIC50:  5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent