BDBM452696 7-methyl-1-[[3- [(1R,5S,6 r)-3-(3- fluorophenyl)-3- azabicyclo[3.1.0] hexan-6-yl]-1,2,4- oxadiazol-5- yl]methyl]purin-6-one::US10711004, Example 16::US10711004, Example 80::US10711004, Example 89

SMILES Cn1cnc2ncn(Cc3nc(no3)[C@@H]3[C@H]4CN(C[C@@H]34)c3cccc(F)c3)c(=O)c12

InChI Key InChIKey=ZZSYQYNHASLYPZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 452696   

LigandPNGBDBM452696(US10711004, Example 16 | 7-methyl-1-[[3- [(1R,5S,6...)
Affinity DataIC50: 4.80nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM452696(US10711004, Example 16 | 7-methyl-1-[[3- [(1R,5S,6...)
Affinity DataIC50: 5.20nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM452696(US10711004, Example 16 | 7-methyl-1-[[3- [(1R,5S,6...)
Affinity DataIC50: 24.6nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM452696(US10711004, Example 16 | 7-methyl-1-[[3- [(1R,5S,6...)
Affinity DataIC50: 33.3nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM452696(US10711004, Example 16 | 7-methyl-1-[[3- [(1R,5S,6...)
Affinity DataIC50: 55.8nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent