BDBM452963 US10711006, Compound I

SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)nc3)c12)C1CCCN(C1)C(=O)C(Br)=C

InChI Key InChIKey=KCPKCAYWGNEVBR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 452963   

TargetTyrosine-protein kinase Blk(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 1.60nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 2.20nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 27nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase CSK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 180nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 350nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 428nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 901nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase HCK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 1.00E+3nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent