BDBM453231 2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenoxy)-N-isopropylacetamide::US10729691, Example 16

SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc(cc2)-c2cn[nH]c2)c2cnn(C)c2n1

InChI Key InChIKey=RCOZVFHWELUVLR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453231   

TargetPutative sugar transporter(malaria parasite P. falciparum)
Kadmon

US Patent
LigandPNGBDBM453231(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-methy...)
Affinity DataIC50:  55nMAssay Description:Parasite cultures were seeded in 96-well plates (1% hematocrit, 1-2% starting parasitemia, 100 μL total volume) with varying concentrations of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM453231(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-methy...)
Affinity DataIC50:  375nMAssay Description:HT1080 cells (as well as other cell types) were plated to confluency in 96-well plates. Cells were exposed to the combination of 10 μM Oligomyci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent