BDBM453245 2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenoxy)-N-neopentylacetamide::US10729691, Example 30

SMILES CC(C)(C)CNC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1

InChI Key InChIKey=XKSKWJHTUPYWCG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453245   

LigandChemical structure of BindingDB Monomer ID 453245BDBM453245(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dih...)
Affinity DataIC50: 55nMAssay Description:HT1080 cells (as well as other cell types) were plated to confluency in 96-well plates. Cells were exposed to the combination of 10 μM Oligomyci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetPutative sugar transporter(malaria parasite P. falciparum)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 453245BDBM453245(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dih...)
Affinity DataIC50: 175nMAssay Description:Parasite cultures were seeded in 96-well plates (1% hematocrit, 1-2% starting parasitemia, 100 μL total volume) with varying concentrations of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent