BDBM453581 (2S)-4-[6-(2-fluoroethyl)-5-methoxy-1- benzothiophen-2-yl]-2-methyl-4- oxobutanoic acid::US10730849, Example 46

SMILES COc1cc2cc(sc2cc1CCF)C(=O)C[C@H](C)C(O)=O

InChI Key InChIKey=WUEMRXKQFMTKLS-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453581   

TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453581((2S)-4-[6-(2-fluoroethyl)-5-methoxy-1- benzothioph...)
Affinity DataEC50:  7.45E+3nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453581((2S)-4-[6-(2-fluoroethyl)-5-methoxy-1- benzothioph...)
Affinity DataEC50:  2.00E+4nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent