BDBM454345 US10717734, Compound 21

SMILES C\C=C(/F)Cn1c(C)c(Oc2ccc(cc2)S(=O)(=O)N(C)C)c2ccccc12

InChI Key InChIKey=YTVZFTJTYZMEBV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 454345   

TargetAmine oxidase [copper-containing] 3(Human)
Pharmaxis

US Patent
LigandPNGBDBM454345(US10717734, Compound 21)
Affinity DataIC50: 3.00E+3nMAssay Description:SSAO/VAP-1: Human recombinant SSAO/VAP-1 amine oxidase activity was determined using the coupled colorimetric method as described for monoamine oxida...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Pharmaxis

US Patent
LigandPNGBDBM454345(US10717734, Compound 21)
Affinity DataIC50: 3.00E+3nMAssay Description:MAO-B: The specificity of the compounds of this invention was tested by determining their ability to inhibit MAO-B activities in vitro. Recombinant h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmaxis

US Patent
LigandPNGBDBM454345(US10717734, Compound 21)
Affinity DataIC50: 3.00E+5nMAssay Description:LOX and LOXL2: Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetOxidized low-density lipoprotein receptor 1(Bovine)
Pharmaxis

US Patent
LigandPNGBDBM454345(US10717734, Compound 21)
Affinity DataIC50: 3.00E+5nMAssay Description:LOX and LOXL2: Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent