BDBM454440 US10717742, Example Ib-163::US10882866, Example Ib-163

SMILES OC(=O)c1cc2nc3[C@@H]4[C@H](CCn3c2cc1F)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12

InChI Key InChIKey=LHSMZMARFUDLBW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454440   

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM454440(US10717742, Example Ib-163 | US10882866, Example I...)
Affinity DataIC50: 2nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM454440(US10717742, Example Ib-163 | US10882866, Example I...)
Affinity DataIC50: 2nMAssay Description:15 μL of compound in 20% DMSO (serial pre-dilutions of compound are done in 100% DMSO) is pipetted to the wells of a white OptiPlate-96 (Perkin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent