BDBM454665 6-(1-isobutyl-1H-indol-5-yl)-N-(1,2,4- thiadiazol-5-yl)pyridine-2- sulfonamide::US10730866, Compound 41

SMILES CC(C)Cn1ccc2cc(ccc12)-c1cccc(n1)S(=O)(=O)Nc1ncns1

InChI Key InChIKey=AXANLPWSYPJODT-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454665   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454665(6-(1-isobutyl-1H-indol-5-yl)-N-(1,2,4- thiadiazol-...)
Affinity DataKi:  322nMAssay Description:The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Mediatech, Inc....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454665(6-(1-isobutyl-1H-indol-5-yl)-N-(1,2,4- thiadiazol-...)
Affinity DataIC50: 514nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent