BDBM454697 6-(1-(4-(trifluoromethyl)benzyl)-1H- indazol-5-yl)picolinamide::US10730866, Compound 105

SMILES NC(=O)c1cccc(n1)-c1ccc2n(Cc3ccc(cc3)C(F)(F)F)ncc2c1

InChI Key InChIKey=CIXHVSBUAHHKOV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454697   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454697(6-(1-(4-(trifluoromethyl)benzyl)-1H- indazol-5-yl)...)
Affinity DataKi:  700nMAssay Description:The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Mediatech, Inc....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454697(6-(1-(4-(trifluoromethyl)benzyl)-1H- indazol-5-yl)...)
Affinity DataIC50: 897nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent