BDBM454699 (S)-1-(6-(1-(4- (trifluoromethyl)benzyl)-1H-indazol- 5-yl)pyridin-2-yl)ethane-1,2-diol::US10730866, Compound 107

SMILES OC[C@@H](O)c1cccc(n1)-c1ccc2n(Cc3ccc(cc3)C(F)(F)F)ncc2c1

InChI Key InChIKey=NSQNXQHRNAHNNQ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454699   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454699((S)-1-(6-(1-(4- (trifluoromethyl)benzyl)-1H-indazo...)
Affinity DataKi:  534nMAssay Description:The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Mediatech, Inc....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454699((S)-1-(6-(1-(4- (trifluoromethyl)benzyl)-1H-indazo...)
Affinity DataIC50: 1.09E+3nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent