BDBM454726 (2R,3S)-2,3-dihydroxy-3-(6-(1- isobutyl-1H-indol-5-yl)pyridin-2- yl)propanamide::US10730866, Compound 150::US10730866, Compound 153

SMILES CC(C)Cn1ccc2cc(ccc12)-c1cccc(n1)[C@H](O)[C@@H](O)C(N)=O

InChI Key InChIKey=HZXOEWIHVAEGFA-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 454726   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454726(US10730866, Compound 150 | (2R,3S)-2,3-dihydroxy-3...)
Affinity DataKi:  678nMAssay Description:The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Mediatech, Inc....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454726(US10730866, Compound 150 | (2R,3S)-2,3-dihydroxy-3...)
Affinity DataIC50: 1.38E+3nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM454726(US10730866, Compound 150 | (2R,3S)-2,3-dihydroxy-3...)
Affinity DataIC50: 2.62E+3nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent