BDBM454918 US10730874, Compound I-3::US10730874, Compound TABLE II.5::US11352356, Table II.5

SMILES Clc1ccn2cnc(CNC(=O)c3ccnc(Cc4ccc5ncc(Cl)cc5c4)c3)c2c1

InChI Key InChIKey=XLKFBGCZLDPHJM-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 454918   

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM454918(US10730874, Compound I-3 | US10730874, Compound TA...)
Affinity DataEC50:  55nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM454918(US10730874, Compound I-3 | US10730874, Compound TA...)
Affinity DataEC50:  55nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM454918(US10730874, Compound I-3 | US10730874, Compound TA...)
Affinity DataEC50:  55nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM454918(US10730874, Compound I-3 | US10730874, Compound TA...)
Affinity DataEC50:  55nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent