BDBM454969 US10730870, Example 138::US10730870, Example 145::US11512083, Example 145

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)c1cc(C)no1

InChI Key InChIKey=LIUCLKNTUXMZEI-RZUBCFFCSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 454969   

Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454969(US10730870, Example 138 | US10730870, Example 145 ...)
Affinity DataIC50:  2.38E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454969(US10730870, Example 138 | US10730870, Example 145 ...)
Affinity DataIC50:  100nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454969(US10730870, Example 138 | US10730870, Example 145 ...)
Affinity DataKd:  10nMAssay Description:The surface plasmon resonance (SPR) experiments were conducted on a Biacore3000 (GE Healthcare). His-tagged VHL protein was immobilized on a carboxym...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454969(US10730870, Example 138 | US10730870, Example 145 ...)
Affinity DataIC50:  100nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent