BDBM455052 US10730874, Compound I-76

SMILES Brc1ccn2cnc(CNC(=O)c3cnn(Cc4cn5cc(cnc5n4)C4CC4)c3)c2c1

InChI Key InChIKey=QPCNCZVIUOQTRX-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 455052   

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandChemical structure of BindingDB Monomer ID 455052BDBM455052(US10730874, Compound I-76)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent