BDBM455299 US10730875, Compound 4

SMILES O=C(Nc1cn2c(cccc2n1)-c1ccc(CN2CCOCC2)cc1)C1CC1

InChI Key InChIKey=GHACUOVXWPZVLY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 455299   

TargetTyrosine-protein kinase JAK1(Human)
Jn Therapeutics

US Patent
LigandPNGBDBM455299(US10730875, Compound 4)
Affinity DataIC50: 750nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN time-resolved fluorescence energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Jn Therapeutics

US Patent
LigandPNGBDBM455299(US10730875, Compound 4)
Affinity DataIC50: 5.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN time-resolved fluorescence energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jn Therapeutics

US Patent
LigandPNGBDBM455299(US10730875, Compound 4)
Affinity DataIC50: 5.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN time-resolved fluorescence energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jn Therapeutics

US Patent
LigandPNGBDBM455299(US10730875, Compound 4)
Affinity DataIC50: 5.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN time-resolved fluorescence energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent