BDBM455786 US10730889, Example 383::tert-Butyl 2-[(pyrazolo[1,5-b]pyridazine-5-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate

SMILES CC(C)(C)OC(=O)N1CCC2(CC2CNC(=O)N2Cc3ccnn3N=C2)CC1

InChI Key InChIKey=BIZQOYLHFFPEST-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 455786   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455786(tert-Butyl 2-[(pyrazolo[1,5-b]pyridazine-5-carbony...)
Affinity DataIC50: 15.8nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
US Patent