BDBM456458 US10723742, Example 184::US11510915, Example 184

SMILES CC(C)(O)Cn1ccc2cc(c(F)cc12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1[C@H]2CC[C@@H]1[C@@H](N)C2

InChI Key InChIKey=OKZIDUHAFBADKZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 456458   

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456458(US10723742, Example 184 | US11510915, Example 184 ...)
Affinity DataIC50: 0.25nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456458(US10723742, Example 184 | US11510915, Example 184 ...)
Affinity DataIC50: 0.25nMAssay Description:To measure the inhibitory activity, first, the Example compound was serially diluted in dimethylsulfoxide (DMSO). Sequentially, the serially diluted ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456458(US10723742, Example 184 | US11510915, Example 184 ...)
Affinity DataIC50: 0.25nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent