BDBM456535 US10723742, Example 264::US10723742, Example 267::US11510915, Example 267

SMILES N[C@H]1C[C@H]2CC[C@@H]1N2C(=O)c1ccc(-c2cc3nnn(CC4(O)CCC4)c3c(C#N)c2F)c(c1)-c1ccc(C#N)c(F)c1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 456535   

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456535(US10723742, Example 264 | US10723742, Example 267 ...)
Affinity DataIC50: 0.240nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456535(US10723742, Example 264 | US10723742, Example 267 ...)
Affinity DataIC50: 0.240nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456535(US10723742, Example 264 | US10723742, Example 267 ...)
Affinity DataIC50: 0.240nMAssay Description:To measure the inhibitory activity, first, the Example compound was serially diluted in dimethylsulfoxide (DMSO). Sequentially, the serially diluted ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456535(US10723742, Example 264 | US10723742, Example 267 ...)
Affinity DataIC50: 0.490nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456535(US10723742, Example 264 | US10723742, Example 267 ...)
Affinity DataIC50: 0.490nMAssay Description:To measure the inhibitory activity, first, the Example compound was serially diluted in dimethylsulfoxide (DMSO). Sequentially, the serially diluted ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM456535(US10723742, Example 264 | US10723742, Example 267 ...)
Affinity DataIC50: 0.490nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent