BDBM457174 US10738052, Example 71::US11261191, Example 71

SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4nccnc4c3)n2c1

InChI Key InChIKey=DEQAARYMSZHDQZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457174   

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM457174(US10738052, Example 71 | US11261191, Example 71)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM457174(US10738052, Example 71 | US11261191, Example 71)
Affinity DataIC50: 500nMAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein was used for the assay. IC50 measurements were based on the degree of phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent