BDBM457464 US10738056, Compound C1181::US10738056, Compound C1222

SMILES Cc1[nH]c2c(c(nn2c(=O)c1-c1nc2ccccc2o1)C#N)-c1ccccc1

InChI Key InChIKey=GDMMSKFCSBRRNA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457464   

TargetCyclic GMP-AMP synthase [155-522](Human)
Aduro Biotech

US Patent
LigandPNGBDBM457464(US10738056, Compound C1181 | US10738056, Compound ...)
Affinity DataIC50: 20nMAssay Description:Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetCyclic GMP-AMP synthase [155-522](Human)
Aduro Biotech

US Patent
LigandPNGBDBM457464(US10738056, Compound C1181 | US10738056, Compound ...)
Affinity DataIC50: 20nMAssay Description:Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent