BDBM457712 2-(8-Amino-3-(5-(1,1-difluoro- 2-hydroxypropan-2-yl)-2- methylphenyl)imidazo[1,2- a]pyrazin-6-yl)-N-(1-hydroxy- 2-methylpropan-2- yl)cyclopropane-1-carboxamide::US10738057, Example 78::US11225486, Example 78
SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)C1CC1C(=O)NC(C)(C)CO)C(C)(O)C(F)F
InChI Key InChIKey=JWUNOCLBEFKXRD-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 457712
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 100nMAssay Description:PI3K-γ: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from PerkinElmer (Waltham, Mass.)....More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 500nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 500nMAssay Description:PI3Kδ: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from PerkinElmer (Waltham, Mass.). ...More data for this Ligand-Target Pair