BDBM458241 US10752615, Compound 139

SMILES C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cccc(NC)n4)s3)nc3ccccc31)C2

InChI Key InChIKey=KITSIKGMHVEYCU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 458241   

TargetTyrosine-protein kinase Tec(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 458241BDBM458241(US10752615, Compound 139)
Affinity DataIC50: 0.380nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase TXK(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 458241BDBM458241(US10752615, Compound 139)
Affinity DataIC50: 0.75nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 458241BDBM458241(US10752615, Compound 139)
Affinity DataIC50: 1.54nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 458241BDBM458241(US10752615, Compound 139)
Affinity DataIC50: 3.95nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent