BDBM458494 4-(tert-butoxyamino)-6-phenyl-N-(2-(trifluoromethyl) pyridin-4-yl)-1,3,5-triazin-2-amine::US10745383, Example 10

SMILES CC(C)(C)ONc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1ccccc1

InChI Key InChIKey=RNCHNCIGFRHHNR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 458494   

TargetIsocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM458494(4-(tert-butoxyamino)-6-phenyl-N-(2-(trifluoromethy...)
Affinity DataIC50:  51.4nMAssay Description:The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent