BDBM458802 5-Ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-(1-isopropylpiperidin-4-yl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzofuran-4-carboxamide::US10759787, Example 10::US11059811, Example 10

SMILES CCc1c(N(CC)C2CCOCC2)cc2oc(C3CCN(C(C)C)CC3)cc2c1C(=O)NCc1c(OC)cc(C)[nH]c1=O

InChI Key InChIKey=LYRIDWLRLOBNIF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 458802   

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 458802BDBM458802(5-Ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2...)
Affinity DataIC50: 1.70nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 458802BDBM458802(5-Ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2...)
Affinity DataIC50: 1.70nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent