BDBM459441 US10752635, Example 3, Peak 1::US11492354, Example 3, Peak 2

SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1cc(F)c2n(C)ncc2c1N1C[C@@H](N)C[C@H]1CO

InChI Key InChIKey=HUAPVUVLSXALII-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 459441   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition constant incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 201nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 530nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed