BDBM460961 US10774053, Compound 81::US11352329, COMPD # 81

SMILES CN(C)C(=O)OC[C@@H](N1C(=N)N[C@@](CC(C)(C)C)(C1=O)c1ccc(cc1)-c1cnn(c1)C(F)F)c1ccc(Cl)c(c1)-c1ncn[nH]1

InChI Key InChIKey=HPKVFXFYAXATBI-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 460961   

TargetEnvelope glycoprotein gp160(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460961(US10774053, Compound 81 | US11352329, COMPD # 81)
Affinity DataIC50: 1.80nMAssay Description:Compounds were tested in a high-throughput 384-well assay format for their ability to inhibit the replication of HIV-1 (IIIB) in MT-4 cells. Compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetGag-Pol polyprotein(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460961(US10774053, Compound 81 | US11352329, COMPD # 81)
Affinity DataIC50: 1.80nMAssay Description:Inhibitor potency against HIV protease was measured using an enzymatic assay with a fluorogenic readout. To a reaction buffer containing 100 mM ammon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetEnvelope glycoprotein gp160(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460961(US10774053, Compound 81 | US11352329, COMPD # 81)
Affinity DataEC50:  31.6nMAssay Description:Assay protocol is identical to that described for the MT-4 antiviral assay with the following changes: Each drug is run in 2 series of quadruplicates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent