BDBM461027 US10774053, Compound 148::US11352329, COMPD # 148

SMILES C[C@H](NC(=O)OC[C@@H](N1C(=N)N[C@@](CC(C)(C)C)(C1=O)c1ccc(-c2cn(nn2)C23CC(C2)C3)c(F)c1)c1ccc(Cl)c(c1)-c1ncnn1C(F)F)C(F)(F)F

InChI Key InChIKey=OMMIQIUADGJCCZ-KOWOYRFJSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 461027   

TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1 group M subtyp...)
Gilead Sciences

US Patent
LigandPNGBDBM461027(US10774053, Compound 148 | US11352329, COMPD # 148)
Affinity DataIC50:  1.70nMAssay Description:Compounds were tested in a high-throughput 384-well assay format for their ability to inhibit the replication of HIV-1 (IIIB) in MT-4 cells. Compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM461027(US10774053, Compound 148 | US11352329, COMPD # 148)
Affinity DataIC50:  1.70nMAssay Description:Inhibitor potency against HIV protease was measured using an enzymatic assay with a fluorogenic readout. To a reaction buffer containing 100 mM ammon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1 group M subtyp...)
Gilead Sciences

US Patent
LigandPNGBDBM461027(US10774053, Compound 148 | US11352329, COMPD # 148)
Affinity DataEC50:  13.8nMAssay Description:Assay protocol is identical to that described for the MT-4 antiviral assay with the following changes: Each drug is run in 2 series of quadruplicates...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent