BDBM461533 US10774071, Example A-109

SMILES COc1nc(ccc1CN[C@@H]1CCCC[C@@H]1O)-c1cccc(c1Cl)-c1cccc2[C@H](CCc12)Nc1nc(OC)c(CNCC(O)=O)nc1C(F)(F)F

InChI Key InChIKey=WFEIRGMSXKTEES-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 461533   

LigandPNGBDBM461533(US10774071, Example A-109)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

LigandPNGBDBM461533(US10774071, Example A-109)
Affinity DataEC50:  37nMAssay Description:Compounds were tested in a functional co-culture reporter assay in which TCR-mediated NFAT activity is inhibited by the engagement of PD-1 with PD-L1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent