BDBM4619 Anilinoquinazoline deriv. 2::CHEMBL1204360::CHEMBL150581::N-(2-Fluorophenyl)-6,7-dimethoxy-4-quinazolinylamine::N-(2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

SMILES COc1cc2ncnc(Nc3ccccc3F)c2cc1OC

InChI Key InChIKey=MBQWMGKHDDVEPF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 4619   

TargetEpidermal growth factor receptor(Human)
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4619BDBM4619(N-(2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 12.8nMAssay Description:Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4619BDBM4619(N-(2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 32.2nMAssay Description:Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4619BDBM4619(N-(2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 2.70E+3nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4619BDBM4619(N-(2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 2.70E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4619BDBM4619(N-(2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 4619BDBM4619(N-(2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 2.60E+4nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 4619BDBM4619(N-(2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed