BDBM462084 3-((4-chloro-3- (methylthio)phenyl)amino)-1- ((3R,4S)-4-cyanotetrahydro-2H- pyran-3-yl)-1H-pyrazole-4- carboxamide::US10766883, Ex-2

SMILES CSc1cc(Nc2nn(cc2C(N)=O)[C@H]2COCC[C@@H]2C#N)ccc1Cl

InChI Key InChIKey=CUSQSZUGMNWENX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 462084   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462084(3-((4-chloro-3- (methylthio)phenyl)amino)-1- ((3R,...)
Affinity DataIC50: 0.25nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462084(3-((4-chloro-3- (methylthio)phenyl)amino)-1- ((3R,...)
Affinity DataIC50: 5.48nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent