BDBM462087 3-((4-cyano-3- isopropylphenyl)amino)-1-((3R,4S)- 4-cyanotetrahydro-2H-pyran-3-yl)- 1H-pyrazole-4-carboxamide::US10766883, Ex-4

SMILES CC(C)c1cc(Nc2nn(cc2C(N)=O)[C@H]2COCC[C@@H]2C#N)ccc1C#N

InChI Key InChIKey=DXKRBQLXARBAFQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 462087   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462087(3-((4-cyano-3- isopropylphenyl)amino)-1-((3R,4S)- ...)
Affinity DataIC50: 0.490nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462087(3-((4-cyano-3- isopropylphenyl)amino)-1-((3R,4S)- ...)
Affinity DataIC50: 9.70nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent