BDBM462088 1-((3R,4S)-4-cyanotetrahydro-2H- pyran-3-yl)-3-((3- methylbenzo[d]isoxazol-5-yl)amino)- 1H-pyrazole-4-carboxamide::US10766883, Ex-5

SMILES Cc1noc2ccc(Nc3nn(cc3C(N)=O)[C@H]3COCC[C@@H]3C#N)cc12

InChI Key InChIKey=OXSCWAKBMHZSCJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 462088   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462088(1-((3R,4S)-4-cyanotetrahydro-2H- pyran-3-yl)-3-((3...)
Affinity DataIC50: 0.160nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462088(1-((3R,4S)-4-cyanotetrahydro-2H- pyran-3-yl)-3-((3...)
Affinity DataIC50: 3.04nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent