BDBM4630 2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenol::Anilinoquinazoline deriv. 13::N-(4-Chloro-2-fluoro-5-hydroxyphenyl)-6-methoxy-7-(2-methoxyethoxy)-4-quinazolinylamine

SMILES COCCOc1cc2ncnc(Nc3cc(O)c(Cl)cc3F)c2cc1OC

InChI Key InChIKey=UCSSQROSBFPVKH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4630   

LigandPNGBDBM4630(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4630(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50: 2nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4630(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50: 7.40E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed