BDBM463152 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{8-[(2,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 6-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cc(O)c(Cl)c(F)c1

InChI Key InChIKey=MDQKRTSVIMQBLN-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463152   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463152(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{...)
Affinity DataKi:  0.0940nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
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Date in BDB:
5/2/2021
Entry Details
US Patent