BDBM463153 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-5-methyl-2-{8- [(2,3,5- trifluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5,7-dihydro- 6H-pyrrolo[2,3-d]pyrimidin-6- one::US10780092, Example 7-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1cc(O)c(Cl)c(F)c1

InChI Key InChIKey=CXVJRKICCBYWLU-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463153   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463153(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-5-m...)
Affinity DataKi:  0.0980nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent