BDBM463179 4-Amino-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-5- methyl-2-{8-[(2,3,5- trifluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5,7-dihydro- 6H-pyrrolo[2,3-d]pyrimidin-6- one::US10780092, Example 33-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1ccc(c(O)c1)C(F)(F)F

InChI Key InChIKey=TVDDCBPPXVYGDK-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463179   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463179(4-Amino-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-5...)
Affinity DataKi:  0.312nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
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Date in BDB:
5/2/2021
Entry Details
US Patent