BDBM463180 4-Amino-2-{8-[(2,4- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-(3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 34-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2F)n1)c1cccc(O)c1

InChI Key InChIKey=GMTAWZMPASOYAS-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463180   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463180(4-Amino-2-{8-[(2,4- difluorophenyl)methyl]imidazo[...)
Affinity DataKi:  0.317nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
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Date in BDB:
5/2/2021
Entry Details
US Patent