BDBM463247 4-(4-Amino-2-{8-[(2,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-6- oxo-6,7-dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 101-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cc(O)c(C#N)c(F)c1

InChI Key InChIKey=FBKXGAKMFNSQQV-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463247   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463247(4-(4-Amino-2-{8-[(2,5- difluorophenyl)methyl]imida...)
Affinity DataKi:  0.162nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent