BDBM463253 4-Amino-2-{8-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyrazin-6-yl}-5-(3-hydroxy-4-methylphenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 107-B

SMILES Cc1ccc(cc1O)C1(C)C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1

InChI Key InChIKey=OWSOOCMTIRAVSL-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463253   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463253(4-Amino-2-{8-[(3-fluorophenyl)methyl]imidazo[1,2-a...)
Affinity DataKi:  0.221nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
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Date in BDB:
5/2/2021
Entry Details
US Patent