BDBM463271 4-Amino-2-(8-benzyl- imidaxol[1,2-a]pyrazin- 6-yl)-5-(3-hydroxyphenyl)- 5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 123-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2)n1)c1cccc(O)c1

InChI Key InChIKey=CULLSKISFGJVOO-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463271   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463271(4-Amino-2-(8-benzyl- imidaxol[1,2-a]pyrazin- 6-yl)...)
Affinity DataKi:  0.372nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent