BDBM463279 5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(3-fluoro- phenyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}-5- methyl-4-[(3,3,3-trifluoro- 2-hydroxypropyl)amino]- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 131-AA::US10780092, Example 131-AB

SMILES CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1

InChI Key InChIKey=RWNKRYZPKPEOAZ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463279   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463279(US10780092, Example 131-AB | 5-(4-Chloro-3-hydroxy...)
Affinity DataKi:  0.347nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463279(US10780092, Example 131-AB | 5-(4-Chloro-3-hydroxy...)
Affinity DataKi:  0.884nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent